APL-5125

APL-5125 (Compound 61f) is a potent, selective and orally active ATP-competitive CK2α inhibitor with an IC50 of 0.348 nM and a Ki of 0.095 nM. APL-5125 binds to CK2α in a bivalent manner, simultaneously interacting with the ATP-binding site and the αD pocket. APL-5125 exhibits antitumor activity and can be used for the research of cancer, such as colon cancer[1].

Product Specifications

CAS Number

[2830619-57-1]

UNSPSC

12352005

Target

Casein Kinase

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(O)C1=CC2=NC(OCCOCCCCNCC3=CC(F)=C(OC(F)(F)F)C(F)=C3)=C4C=CN=CC4=C2C=C1

Molecular Formula

C27H24F5N3O5

Molecular Weight

565.49

References & Citations

[1]Glossop PA, et al. Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors. J Med Chem. 2025 Oct 23;68 (20) :21587-21614.