APL-5125
APL-5125 (Compound 61f) is a potent, selective and orally active ATP-competitive CK2α inhibitor with an IC50 of 0.348 nM and a Ki of 0.095 nM. APL-5125 binds to CK2α in a bivalent manner, simultaneously interacting with the ATP-binding site and the αD pocket. APL-5125 exhibits antitumor activity and can be used for the research of cancer, such as colon cancer[1].
Product Specifications
CAS Number
2830619-57-1
UNSPSC
12352005
Target
Casein Kinase
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(O)C1=CC2=NC(OCCOCCCCNCC3=CC(F)=C(OC(F)(F)F)C(F)=C3)=C4C=CN=CC4=C2C=C1
Molecular Formula
C27H24F5N3O5
Molecular Weight
565.49
References & Citations
[1]Glossop PA, et al. Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors. J Med Chem. 2025 Oct 23;68 (20) :21587-21614.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
IRBAMLBDH1AP789200UL 200 µL
Rabbit Anti BDH1 Polyclonal Affinity Purified (PBS with 0.05% sodium azide and 50% glycerol, pH7.4) (IHC,ELISA) 200ul
Sign In for Pricing
View Details S6567-50PK 1 mg
SRm160 (Serine/Arginine Repetitive Matrix 1, Serine/Arginine-Related Nuclear Matrix Protein) Control Peptide (KLH) discontinued
Sign In for Pricing
View Details 
