α, δ-NAG

α, δ-NAG is an orally active glutaminase-resistant less-hydrolyzable L-Glutamine derivative. α, δ-NAG is a G protein-coupled receptor (GPCR) allosteric modulator. α, δ-NAG suppresses neutrophilic airway inflammation by activating the GPCR/ERK/MKP-1 pathway. α, δ-NAG can be used for the researches of inflammation and immunology, such as asthma[1].

Product Specifications

CAS Number

[3051899-13-6]

UNSPSC

12352211

Target

Drug Derivative; ERK; Phosphatase; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(NC(C)=O)CC[C@H](C(O)=O)NC(C)=O

Molecular Formula

C9H14N2O5

Molecular Weight

230.22

References & Citations

[1]Kim J M, et al. α, δ-N-Acetyl-glutamine Suppresses Neutrophilic Airway Inflammation by Activating the G Protein-Coupled Receptor/Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Phosphatase 1 Pathway[J]. ACS Pharmacology & Translational Science, 2025.