STK10-IN-1

SLK/STK10-IN-2 (Compound 23) is a highly selective STK10 inhibitor, with a Kd of 365 nM and an IC50 of 0.85 μM. SLK/STK10-IN-2 exhibits EC50 of 0.89 μM in NanoBRET cell experiments. SLK/STK10-IN-2 shows no significant binding to SLK, STK3/4. SLK/STK10-IN-2 can be used to study STK10-related diseases (such as abnormal lymphocyte migration) [1].

Product Specifications

UNSPSC

12352005

Target

Ser/Thr Kinase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CC1=CC(Cl)=CC=C1CNC(NC2=CC=C3C=C2OCCOCCNC4=NC5=C3C=NN5C=C4)=O

Molecular Formula

C25H25ClN6O3

Molecular Weight

492.96

References & Citations

[1]Dettenhöfer M, et al. Un-LOK-ing a New Approach for Conformational Selective Targeting of STK10 (LOK) . ACS Med Chem Lett. 2025 Oct 14;16 (11) :2086-2096.