HDAC11-IN-4

HDAC11-IN-4 is a potent and selective HDAC11 inhibitor with an IC50 of 13.49 nM and a Ki of 2.2 nM. HDAC11-IN-4 exhibits extremely high selectivity for HDAC11 over other defatty-acylases such as SIRT2, SIRT3, SIRT6, and HDAC8 (SI >10,000) . HDAC11-IN-4 can be used for the research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

CCCCCCCCCCCCSC[C@H](C(NCCCC[C@@H]1NC([C@@H](NC1=O)CCC(N)=O)=O)=O)N

Molecular Formula

C26H49N5O4S

Molecular Weight

527.76

References & Citations

[1]Sebastian Hilscher, et al. Substrate-Guided Development of HDAC11-Selective Inhibitors Featuring α-Amino Amide Zinc-Binding Groups. ACS Omega 2025, 10, 42, 50577–50587