HDAC11-IN-4
HDAC11-IN-4 is a potent and selective HDAC11 inhibitor with an IC50 of 13.49 nM and a Ki of 2.2 nM. HDAC11-IN-4 exhibits extremely high selectivity for HDAC11 over other defatty-acylases such as SIRT2, SIRT3, SIRT6, and HDAC8 (SI >10,000) . HDAC11-IN-4 can be used for the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
CCCCCCCCCCCCSC[C@H](C(NCCCC[C@@H]1NC([C@@H](NC1=O)CCC(N)=O)=O)=O)N
Molecular Formula
C26H49N5O4S
Molecular Weight
527.76
References & Citations
[1]Sebastian Hilscher, et al. Substrate-Guided Development of HDAC11-Selective Inhibitors Featuring α-Amino Amide Zinc-Binding Groups. ACS Omega 2025, 10, 42, 50577–50587
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC11
Frequently Asked Questions
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