DRAK1/2-IN-2
DRAK1/2-IN-2 (Compound Y17) is a DRAK1/2 inhibitor with IC50 values for DRAK2 and DRAK1 of 353.2 nM and 507.4 nM respectively. DRAK1/2-IN-2 can enhance mitochondrial membrane potential and glucose-stimulated insulin secretion (GSIS) . DRAK1/2-IN-2 resists lipotoxicity-induced cell apoptosis. DRAK1/2-IN-2 significantly inhibits the secretion of pro-inflammatory cytokine IL-1β, thereby exerting an anti-inflammatory effect. DRAK1/2-IN-2 can significantly lower the blood glucose levels of mice. DRAK1/2-IN-2 can be used in diabetes research.
Product Specifications
UNSPSC
12352005
Target
Apoptosis; DAPK; Endogenous Metabolite; Interleukin Related
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(NC1=CSC2=NC=C(C=C12)C(C=C3OC)=CC=C3NCCC(O)=O)C4CCCCC4
Molecular Formula
C24H27N3O4S
Molecular Weight
453.55
References & Citations
[1]Lian K, et al. Novel thieno[2,3-b]pyridine derivatives protect islet through DRAK2 kinase inhibition. Eur J Med Chem. 2026 Jan 5;301:118258.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DAPK1; DAPK2; IL-1
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