STING agonist-48
STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC50 = 4.02 μM) . STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases[1].
Product Specifications
CAS Number
3027712-31-5
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(C1=CC=C(N2CC3=C(O)C=CC=C3F)C(SCC2=O)=C1)NCC4=C(F)C=C(F)C=C4F
Molecular Formula
C23H16F4N2O3S
Molecular Weight
476.44
References & Citations
[1]Junaid A, et al. In silico discovery and mechanistic profiling of STING agonists engaging the transmembrane domain. Eur J Med Chem. 2026 Jan 5;301:118201.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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