STING agonist-48

STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC50 = 4.02 μM) . STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases[1].

Product Specifications

CAS Number

[3027712-31-5]

Target

STING

Related Pathways

Immunology/Inflammation

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C(C1=CC=C(N2CC3=C(O)C=CC=C3F)C(SCC2=O)=C1)NCC4=C(F)C=C(F)C=C4F

Molecular Formula

C23H16F4N2O3S

Molecular Weight

476.44

References & Citations

[1]Junaid A, et al. In silico discovery and mechanistic profiling of STING agonists engaging the transmembrane domain. Eur J Med Chem. 2026 Jan 5;301:118201.