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Nav1.2-IN-2

Nav1.2-IN-2 (Compound 1) is a Nav1.2 inhibitor with an IC₅₀ for inactivating Nav1.2 of 0.18 μM. Nav1.2-IN-2 can effectively suppress the amplitude and frequency of spontaneous synchronous calcium oscillations (SCOs), with IC₅₀ values of 0.38 μM and 0.88 μM respectively. Nav1.2-IN-2 inhibits Ca2+ influx induced by Veratridine , with an IC₅₀ of 1.89 μM. Nav1.2-IN-2 can be used for the study of diseases such as epilepsy[1].

Product Specifications

CAS Number

7469-49-0

UNSPSC

12352005

Target

Calcium Channel; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Purity

99.82

Solubility

DMSO : 4.17 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C)C(NC(OCCCC)=O)=C1)OCCCC

Molecular Formula

C17H26N2O4

Molecular Weight

322.40

References & Citations

[1]Xu J, et al. Aniline analogues as synchronized Ca2+ oscillation modulators: structure-activity relationship and mechanism. Eur J Med Chem. 2026 Jan 5;301:118267.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Nav1.2

Available Sizes

Frequently Asked Questions

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