Hsp90β-IN-2
Hsp90β-IN-2 (Compound 16B) is a selective Hsp90β inhibitor with KDs of 225 nM and 73.32 μM against Hsp90β and Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231 cells, A549 and SKOV-3 cells. KUNB106 can be used for the study of triple negative breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
HSP
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CCCC1=CC2=C(C(N3CCC(CC3)O)=CC(N4N=C(C5=C4CC(C)(CC5=O)C)CC)=C2)C(N1)=O
Molecular Formula
C28H36N4O3
Molecular Weight
476.61
References & Citations
[1]Serwetnyk MA, et al. Optimization of an Hsp90β-selective inhibitor via exploration of the Hsp90 N-terminal ATP-binding pocket. Eur J Med Chem. 2025 Nov 5;297:117925.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Curated Selection
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