IDO1-IN-32

IDO1-IN-32 (Compound 45) is a potent and orally effective IDO1 inhibitor with an IC50 of 10 pM. IDO1-IN-32 exhibits significant anti-proliferative activity against Hela cells. IDO1-IN-32 can significantly inhibit tumor growth in CT26 and LCC transplanted mouse models by activating anti-tumor immunity. IDO1-IN-32 can be used for research on colon cancer and breast cancer[1].

Product Specifications

CAS Number

[2456309-77-4]

Target

Indoleamine 2,3-Dioxygenase (IDO)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(C1=CC=CN1C2=CC(NC(NC3=CC=C(Cl)C=C3F)=O)=C(N(CC(C)C)CC(C)C)C(Cl)=C2)O

Molecular Formula

C26H29Cl2FN4O3

Molecular Weight

535.44

References & Citations

[1]Zou Y, et al. 1- (3,4-Diaminophenyl) -1H-pyrrole-2-carboxylic acids as potent apo-IDO1 inhibitors exhibiting efficacy in syngeneic tumor mouse models. Eur J Med Chem. 2026 Jan 5;301:118222.