STING-IN-17
STING-IN-17 is an orally active STING (human STING IC50 = 29 nM, mouse STING IC50 = 15 nM) inhibitor. STING-IN-17 can inhibit the phosphorylation of STING, TBK1 and IRF3. STING-IN-17 dose dependently inhibits the mRNA expression of IP10, IFNB1 and ISG56. STING-IN-17 can reduce ROS and inhibit the expression of cleaved-PARP/caspase-3. STING-IN-17 can improve kidney function. STING-IN-17 can be used for research on inflammatory conditions such as acute kidney injury[1].
Product Specifications
CAS Number
[3069635-58-8]
UNSPSC
12352005
Target
Caspase; IFNAR; IKK; PARP; Reactive Oxygen Species (ROS) ; STING
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=C(C(C)(C)C(N2CC3CN(C4=CC(C(F)(F)F)=CC(F)=C4)C3)=O)C2=C1)NC5=CNC6=C5C=CC=C6
Molecular Formula
C30H26F4N4O2
Molecular Weight
550.55
References & Citations
[1]Li W, et al. Discovery of a potent and orally bioavailable 3,3-dimethyl-2-oxoindoline STING inhibitor. Eur J Med Chem. 2026 Jan 5;301:118232.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; TBK1
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