IA107
IA107 is a potent, selective, and allosteric IRE1α RNase (IC50 = 16 nM (non phosphorylated), IC50 = 9 nM (phosphorylated) ) inhibitor. IA107 can inhibit endoplasmic reticulum stress-induced XBP1 mRNA splicing and protein expression, and has no cytotoxicity[1].
Product Specifications
UNSPSC
12352005
Target
IRE1
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Smiles
CC1=C(C2=CC(Br)=CC=C2N1C(C3=CC=CC=C3)=O)CCC(O)=O
Molecular Formula
C19H16BrNO3
Molecular Weight
386.24
References & Citations
[1]Liu Y, et al. Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing. Nat Commun. 2025 Sep 26;16 (1) :8531.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-178946/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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