IA107

IA107 is a potent, selective, and allosteric IRE1α RNase (IC50 = 16 nM (non phosphorylated), IC50 = 9 nM (phosphorylated) ) inhibitor. IA107 can inhibit endoplasmic reticulum stress-induced XBP1 mRNA splicing and protein expression, and has no cytotoxicity[1].

Product Specifications

UNSPSC

12352005

Target

IRE1

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Smiles

CC1=C(C2=CC(Br)=CC=C2N1C(C3=CC=CC=C3)=O)CCC(O)=O

Molecular Formula

C19H16BrNO3

Molecular Weight

386.24

References & Citations

[1]Liu Y, et al. Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing. Nat Commun. 2025 Sep 26;16 (1) :8531.