IA107
IA107 is a potent, selective, and allosteric IRE1α RNase (IC50 = 16 nM (non phosphorylated), IC50 = 9 nM (phosphorylated) ) inhibitor. IA107 can inhibit endoplasmic reticulum stress-induced XBP1 mRNA splicing and protein expression, and has no cytotoxicity[1].
Product Specifications
UNSPSC
12352005
Target
IRE1
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Smiles
CC1=C(C2=CC(Br)=CC=C2N1C(C3=CC=CC=C3)=O)CCC(O)=O
Molecular Formula
C19H16BrNO3
Molecular Weight
386.24
References & Citations
[1]Liu Y, et al. Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing. Nat Commun. 2025 Sep 26;16 (1) :8531.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
T0850-05C 50 µg
Tamm-Horsfall Glycoprotein (Uromucoid, THgp, THP, Uromodulin, UMOD) (Biotin)
Sign In for Pricing
View Details ![[KO Validated] EEF2K Rabbit pAb (APR25802N)](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
LV672595 1.0 µg DNA
EIF2B5 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details 
A110-322A 0.5 mg
Rabbit anti-Rat IgG Heavy and Light Chain Cross-Adsorbed Antibody Affinity Purified
Sign In for Pricing
View Details