CDC25-IN-1
CDC25-IN-1 (Compound D11b) is a potent inhibitor of cell division cycle 25 (CDC25) phosphatase. CDC25-IN-1 exerts strong inhibitory effects on leukemia and colorectal cancer cells. CDC25-IN-1 blocks CDC25 mediated CDK1 Tyr15 dephosphorylation, delays G2/M progression, and induces caspase-dependent apoptosis with DNA damage. CDC25-IN-1 can be used for researches of leukemia and colorectal cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Caspase; Phosphatase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=CC=CN=C12)C(NCCN(C)C)=C(Cl)C2=O
Molecular Formula
C13H14ClN3O2
Molecular Weight
279.72
References & Citations
[1]Narwanti I, et al. Quinoline-5,8-dione CDC25 inhibitors: Potent anti-cancer agents in leukemia and patient-derived colorectal organoids. Eur J Med Chem. 2026 Jan 5;301:118215.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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