Neuroprotective agent 15
Neuroprotective agent 15 (Compound 3e) is a neuroprotective agent. Neuroprotective agent 15 is a selective butyrylcholinesterase (BChE) inhibitor, with IC50 values of 2.6 and 114.3 μM for BChE and AChE respectively. Neuroprotective agent 15 has cannabinoid CB2 receptor (CB2 receptor) agonistic activity. Neuroprotective agent 15 can reduce cell death, LDH release and Caspase-3/7 activity, and inhibit apoptosis. Neuroprotective agent 15 can reduce the formation of superoxide free radicals, maintain cell morphology, and significantly lower oxidative stress levels. Neuroprotective agent 15 can be used in the research of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease[1].
Product Specifications
CAS Number
2476614-40-9
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH) ; Apoptosis; Cannabinoid Receptor; Caspase; Cholinesterase (ChE)
Related Pathways
Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
OC1=CC=C(CN2C3=NC(N4CCCC4)=NC(N5CCCC5)=C3N=C2)C=C1
Molecular Formula
C20H24N6O
Molecular Weight
364.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; Caspase 3; Caspase 7; CB2
Frequently Asked Questions
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