Neuroprotective agent 15

Neuroprotective agent 15 (Compound 3e) is a neuroprotective agent. Neuroprotective agent 15 is a selective butyrylcholinesterase (BChE) inhibitor, with IC50 values of 2.6 and 114.3 μM for BChE and AChE respectively. Neuroprotective agent 15 has cannabinoid CB2 receptor (CB2 receptor) agonistic activity. Neuroprotective agent 15 can reduce cell death, LDH release and Caspase-3/7 activity, and inhibit apoptosis. Neuroprotective agent 15 can reduce the formation of superoxide free radicals, maintain cell morphology, and significantly lower oxidative stress levels. Neuroprotective agent 15 can be used in the research of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease[1].

Product Specifications

CAS Number

[2476614-40-9]

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH) ; Apoptosis; Cannabinoid Receptor; Caspase; Cholinesterase (ChE)

Related Pathways

Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC1=CC=C(CN2C3=NC(N4CCCC4)=NC(N5CCCC5)=C3N=C2)C=C1

Molecular Formula

C20H24N6O

Molecular Weight

364.44

References & Citations

[1]Kordinová H, et al. Development of 2,6,9-trisubstituted purines as neuroprotective agents targeting butyrylcholinesterase and cannabinoid CB2 receptor. Eur J Med Chem. 2026 Jan 5;301:118217.