DHODH-IN-32

DHODH-IN-32 (Compound A1) is a DHODH inhibitor. DHODH-IN-32 shows significant cytotoxicity against NCI-60 cell lines, especially being sensitive to breast cancer, prostate cancer and leukemia cell lines. DHODH-IN-32 can induce cell apoptosis by activating the Caspase pathway. DHODH-IN-32 causes G0/G1 phase cell cycle arrest and inhibits cellular metabolism by ROS. DHODH-IN-32 exhibits significant anti-tumor properties in mouse breast cancer models. DHODH-IN-32 can be used for the study of breast cancer[1].

Product Specifications

UNSPSC

12352101

Target

Apoptosis; Caspase; Dihydroorotate Dehydrogenase; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C[Se]C#N)NC1=CC(C(F)(F)F)=CC=C1

Molecular Formula

C10H7F3N2OSe

Molecular Weight

307.13

References & Citations

[1]Morán-Serradilla C, et al. Synthesis and characterization of novel phenyl carboxamide-selenium analogs: Identification of a potent DHODH inhibitor as a potential anticancer agent. Eur J Med Chem. 2026 Jan 5;301:118193.