Apoptosis inducer 49

Apoptosis inducer 49 is a selective apoptosis inducer with high specificity against CCRF-CEM leukemia cells (IC50 = 2.68 μM) . Apoptosis inducer 49 enhances RNA synthesis and replication stress, activates the Chk1-p21 axis, leading to S-phase arrest. Apoptosis inducer 49 can inhibit Bcl-2 and activate caspase-3. Apoptosis inducer 49 can be used for the study of Leukemia[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; CDK; Checkpoint Kinase (Chk) ; DNA/RNA Synthesis

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C6=CN(CC7=CC=CO7)N=N6)=C)CC[C@@](CO)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]

Molecular Formula

C36H53N3O3

Molecular Weight

575.82

References & Citations

[1]Orság Š, et al. Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells. Eur J Med Chem. 2025 Oct 16;302 (Pt 1) :118268.