JAK2-IN-15
JAK2-IN-15 is an orally active, potent, selective JAK2 inhibitor (IC50 = 1.17 nM) . JAK2-IN-15 can inhibit the AK2-STAT signaling pathway. JAK2-IN-15 significantly improves key pathological indicators such as hematocrit and splenomegaly in an Epoetin beta (HY-114134) (rhEPO) -induced mouse model. JAK2-IN-15 can be used for the study of Polycythemia Vera (PV) [1].
Product Specifications
Target
JAK; STAT
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
CC1=C2N=C(NC3=CC=C(C(COC/C=C/COCC4=CC=CC(N2)=C4)=C3)OCCN5CCOCC5)N=C1
Molecular Formula
C29H35N5O4
Molecular Weight
517.62
References & Citations
[1]Hu F, et al. Exploring the macrocyclic chemical space for heuristic drug design with deep learning models. Commun Chem. 2025 Oct 7;8 (1) :299.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-178936/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2
CAS Number
[3094174-82-7]
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