RAGE406R
RAGE406R is an orally active RAGE-DIAPH1 interaction antagonist. RAGE406R can bind to ctRAGE and prevent the formation of the RAGE-DIAPH1 complex and inhibit its interaction. RAGE406R can reduce the expression of CCL2, TNF, and IL-6 in THP1 cells. RAGE406R suppresses delayed-type hypersensitivity in T2D mice. RAGE406R can be used for the study of diabetes[1].
Product Specifications
CAS Number
3034560-21-6
Target
CCR; Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation
Field of Research
Endocrinology; Metabolic Disease; Inflammation/Immunology
Smiles
N#CC1=CC=C2C(CN3CCOCC3)=CC(C4=CC=C(C=C4)[C@H]5CCC(N5)=O)=NC2=C1
Molecular Formula
C25H24N4O2
Molecular Weight
412.48
References & Citations
[1]Theophall GG, et al. RAGE-mediated activation of the formin DIAPH1 and human macrophage inflammation are inhibited by a small molecule antagonist. Cell Chem Biol. 2025 Oct 16;32 (10) :1221-1234.e8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6
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