NNRT-IN-14

NNRT-IN-14 is an HIV-1 reverse transcriptase inhibitor (IC50 = 0.175 µM) . NNRT-IN-14 can form hydrogen bonds with LYS101, PRO225, and PHE227, and π–π stacking with TYR181 and TRP229. NNRT-IN-14 can be used for the study of HIV[1].

Product Specifications

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC1=C(OC2=C(C=NC=C3)C3=NC(NC4=CC=C(C#N)C=N4)=C2)C(C)=CC(/C=C/C#N)=C1

Molecular Formula

C25H18N6O

Molecular Weight

418.45

References & Citations

[1]Baicharoen A, et al. Discovery and molecular docking studies of nitrogen containing naphthyridine derivatives as potent HIV1 NNRTIs with anticancer potential. Sci Rep. 2025 Oct 1;15 (1) :32622.