CAI/II-IN-13
CAI/II-IN-13 (Compound 5f) is a CAI/II inhibitor, with IC50 values of 309.16 nM for hCA I and 267.27 nM for hCA II. CAI/II-IN-13 exhibits potent and selective antiproliferative activity against A549 lung cancer cells (IC50 = 0.58 μM) . CAI/II-IN-13 can be used for the study of lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
OC1CCN(CC1)C2=CC=C(C=C2)/C=N/NC(NC3=C(C(Cl)=CC=C3)Cl)=S
Molecular Formula
C19H20Cl2N4OS
Molecular Weight
423.36
References & Citations
[1]Aftab H, et al. Synthesis, antiproliferative activity targeting lung cancer and in silico studies of hydroxypiperidine substituted thiosemicarbazones. Sci Rep. 2025 Sep 29;15 (1) :33402.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I
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