CAI/II-IN-13

CAI/II-IN-13 (Compound 5f) is a CAI/II inhibitor, with IC50 values of 309.16 nM for hCA I and 267.27 nM for hCA II. CAI/II-IN-13 exhibits potent and selective antiproliferative activity against A549 lung cancer cells (IC50 = 0.58 μM) . CAI/II-IN-13 can be used for the study of lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

OC1CCN(CC1)C2=CC=C(C=C2)/C=N/NC(NC3=C(C(Cl)=CC=C3)Cl)=S

Molecular Formula

C19H20Cl2N4OS

Molecular Weight

423.36

References & Citations

[1]Aftab H, et al. Synthesis, antiproliferative activity targeting lung cancer and in silico studies of hydroxypiperidine substituted thiosemicarbazones. Sci Rep. 2025 Sep 29;15 (1) :33402.