N-19004

N-19004 is a FPR1 antagonist. N-19004 shows broad-spectrum antibacterial effects against a variety of pathogens. N-19004 exhibits significant retinal protective effects in the rd10 mouse model of retinitis pigmentosa (RP) . N-19004 can attenuate retinal dysfunction, mitigate rod and cone degeneration, and reduce immune cell activation, gliosis, inflammation, oxidative stress, and apoptosis. N-19004 can reduce the size of laser-induced choroidal lesions and promote edema absorption through dual anti-inflammatory and anti-angiogenic effects. N-19004 can be used for the research of retinal degenerative diseases such as retinitis pigmentosa[1][2].

Product Specifications

CAS Number

[2996841-28-0]

UNSPSC

12352005

Target

Apoptosis; Bacterial; Formyl Peptide Receptor (FPR)

Related Pathways

Anti-infection; Apoptosis; GPCR/G Protein

Field of Research

Inflammation/Immunology

Smiles

CC(C)(C1=CC(NC(CC/N=C(N)/N)=O)=C(C(NC(CC/N=C(N)/N)=O)=C1)SCC2=CC=C3C=CC=CC3=C2)C

Molecular Formula

C29H38N8O2S

Molecular Weight

562.73

References & Citations

[1]Amato R, et al. Inhibiting The uPA/uPAR Pathway Affords Photoreceptor Resilience and Preserves Retinal Function in a Mouse Model of Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2025 Aug 1;66 (11) :29.|[2]De Fenza M, et al. Dual-action thioarylamide-based small molecules to target drug-resistant bacteria and chronic inflammation. iScience. 2025 Oct 3;28 (11) :113674.