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XZA-1

XZA-1 is a 3-hydroxyacyl-coenzyme A dehydrogenase (HADH) activator. XZA-1 increases the intracellular level of acetoacetyl-CoA, which in turn induces acetoacetylation modification of Chromobox Protein Homolog 4 (CBX4) at lysine 106 (K106) . XZA-1 exhibits antitumor effects in a xenograft model of human hepatocellular carcinoma SMMC7721 cells overexpressing CBX4. XZA-1 can be used for the study of hepatocellular carcinoma[1].

Product Specifications

CAS Number

1282141-20-1

UNSPSC

12352005

Target

Others

Related Pathways

Others

Field of Research

Cancer

Smiles

O=C(C1=NOC2=C1CCCCC2)NC3=CC=CC=C3

Molecular Formula

C15H16N2O2

Molecular Weight

256.30

References & Citations

[1]Li H, et al. CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity. Cell Chem Biol. 2025 Oct 16;32 (10) :1249-1259.e9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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