XZA-1
XZA-1 is a 3-hydroxyacyl-coenzyme A dehydrogenase (HADH) activator. XZA-1 increases the intracellular level of acetoacetyl-CoA, which in turn induces acetoacetylation modification of Chromobox Protein Homolog 4 (CBX4) at lysine 106 (K106) . XZA-1 exhibits antitumor effects in a xenograft model of human hepatocellular carcinoma SMMC7721 cells overexpressing CBX4. XZA-1 can be used for the study of hepatocellular carcinoma[1].
Product Specifications
CAS Number
1282141-20-1
UNSPSC
12352005
Target
Others
Related Pathways
Others
Field of Research
Cancer
Smiles
O=C(C1=NOC2=C1CCCCC2)NC3=CC=CC=C3
Molecular Formula
C15H16N2O2
Molecular Weight
256.30
References & Citations
[1]Li H, et al. CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity. Cell Chem Biol. 2025 Oct 16;32 (10) :1249-1259.e9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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