ITA-5
ITA-5 is a TBK1 inhibitor based on the structure of itaconic acid. can significantly inhibit the secretion of IFN-β. ITA-5 can inhibit the phosphorylation of TBK1, IRF3, and STAT1. ITA-5 can be used for research on autoimmune diseases and excessive inflammation[1].
Product Specifications
CAS Number
[2374162-36-2]
Target
IFNAR; IKK; STAT
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
C=C(C(N[C@H](C(OC)=O)CC1=CC=CC=C1)=O)CC(OC)=O
Molecular Formula
C16H19NO5
Molecular Weight
305.33
References & Citations
[1]Chai L, et al. IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1. Cell Rep. 2025 Oct 28;44 (10) :116336.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT1; TBK1
Curated Selection
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