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ITA-5

ITA-5 is a TBK1 inhibitor based on the structure of itaconic acid. can significantly inhibit the secretion of IFN-β. ITA-5 can inhibit the phosphorylation of TBK1, IRF3, and STAT1. ITA-5 can be used for research on autoimmune diseases and excessive inflammation[1].

Product Specifications

CAS Number

2374162-36-2

Target

IFNAR; IKK; STAT

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

C=C(C(N[C@H](C(OC)=O)CC1=CC=CC=C1)=O)CC(OC)=O

Molecular Formula

C16H19NO5

Molecular Weight

305.33

References & Citations

[1]Chai L, et al. IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1. Cell Rep. 2025 Oct 28;44 (10) :116336.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT1; TBK1

Frequently Asked Questions

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