Tyk2-IN-23
Tyk2-IN-23 is a potent, orally active, selective TYK2 inhibitor (IC50 = 18 nM), exhibiting more than > 70-fold selectivity over JAK1/2/3 isoforms. Tyk2-IN-23 potently inhibits p-STAT3 in TYK2-dependent signaling activated by IFN-α and IL-10. Tyk2-IN-23 potently inhibits IFN-α-induced STAT1 phosphorylation in H9 cells. Tyk2-IN-23 can be used for the study of alopecia areata and allergic Rhinitis[1].
Product Specifications
CAS Number
2734918-75-1
Target
JAK; STAT
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O=C1NCCC21CCN(C3=C(C)C=NC(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)=N3)CC2
Molecular Formula
C26H27ClFN5O2
Molecular Weight
495.98
References & Citations
[1]Tian Y, et al. Identification of a novel benzyloxy-terminated scaffold as a potent and selective TYK2 inhibitor for anti-inflammatory therapy. Eur J Med Chem. 2026 Jan 5;301:118211.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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