Mcl-1-IN-20
Mcl-1-IN-20 (Compound 26d) is a Mcl-1 inhibitor with Kis of 0.59, 6.6 and 3.6 μM against Mcl-1, Bcl-xL and Bcl-2. Mcl-1-IN-20 exhibits significant anti-proliferative activity against pancreatic cancer cells and can induce apoptosis in BxPC-3 cells. Mcl-1-IN-20 can be used for the study of pancreatic cancer[1].
Product Specifications
Target
Apoptosis; Bcl-2 Family
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(NS(=O)(C1=CC=C(Cl)C([N+]([O-])=O)=C1)=O)CN2C(SCCOC3=C4C=CC=CC4=CC=C3)=NC5=CC=CC(C6=CC=C(CC)C=C6)=C25
Molecular Formula
C35H29ClN4O6S2
Molecular Weight
701.21
References & Citations
[1]Nie Y, et al. Discovery of benzimidazole-based Mcl-1 inhibitors via AlphaShape-enabled virtual screening. Eur J Med Chem. 2026 Jan 5;301:118229.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL; Mcl-1
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