FLT3-IN-35
FLT3-IN-35 (Compound 4K) is an orally active, covalent, irreversible FLT3 inhibitor. FLT3-IN-35 inhibits the phosphorylation of FLT3 and its downstream signaling factors, as well as induces cell cycle arrest and apoptosis. FLT3-IN-35 inhibits the phosphorylation of FLT3 and its downstream signaling factors, as well as induced cell cycle arrest and apoptosis. FLT3-IN-35 can be used for the study of acute myeloid leukemia (AML) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FLT3
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN(CC1)CCN1C(C(C)=C2)=CC=C2NC3=NC=C4C(C(C5=CC=CC=C5NC(C=C)=O)=CC=C4)=N3
Molecular Formula
C29H30N6O
Molecular Weight
478.59
References & Citations
[1]Wei W, et al. Design, synthesis and biological evaluation of 8-phenylquinazolin-2-amine derivatives as FLT3 covalent inhibitors targeting cysteine 828 in the ATP pocket. Eur J Med Chem. 2026 Jan 5;301:118212.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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