SERT/5-HT-IN-1

SERT/5-HT-IN-1 is an orally active and potent dual target inhibitor of SERT/5-HT3A (SERT IC50 = 1.5 nM, NET IC50 = 49 nM, DAT IC50 = 91 nM, 5-HT3A Ki = 12 nM) . SERT/5-HT-IN-1 has an IC50 of 39 nM to 5-HT3A. SERT/5-HT-IN-1 has a lower risk of liver, kidney, and cardiac toxicity. SERT/5-HT-IN-1 can be used for research on depressive disorders[1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor; Serotonin Transporter

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

N1(C2=C(SC=C3)C3=CC=C2)CCC4(CNC4)CC1

Molecular Formula

C15H18N2S

Molecular Weight

258.38

References & Citations

[1]Zheng J, et al. Design, synthesis, and biological profiling of novel aryl-spirocyclic diamine derivatives with potential antidepressant-like properties. Eur J Med Chem. 2026 Jan 5;301:118198.