PROTAC K-Ras Degrader-7
PROTAC K-Ras Degrader-7 is a potent PROTAC K-Ras degrader. PROTAC K-Ras Degrader-7 degrades K-Ras through recruiting the Keap1 E3 ubiquitin ligase. PROTAC K-Ras Degrader-7 can be used for research in pancreatic and colorectal cancers. (Pink: Nrf2 ligand: Nrf2 activator-22 (HY-178875) ; Blue: E3 ligand (HY-178874) ; target protein ligand+linker (HY-178888) [1].
Product Specifications
UNSPSC
12352005
Target
Keap1-Nrf2; PROTACs; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; NF-κB; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
Molecular Formula
C64H65F3N10O10S
Molecular Weight
1223.32
References & Citations
[1]Austin J, et al. PROTAC Compounds Binding Keap1 Ubiquitin Ligase for Targeted Protein Degradation. WO2025085815A1. 2025-04-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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