OX2-2303

OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research[1].

Product Specifications

CAS Number

1607428-33-0

Target

Orexin Receptor (OX Receptor)

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

FC1=CC(C(N2C[C@H](OC3=NC=CC(C#N)=C3C)CC[C@H]2C)=O)=C(C4=NC=CS4)C=C1

Molecular Formula

C23H21FN4O2S

Molecular Weight

436.50

References & Citations

[1]1. Rong J, et al. Development of Novel 18F‑Labeled Selective Orexin‑2 Receptor Radioligands for Positron Emission Tomography. ACS Pharmacol. Transl. Sci. 2025.