FLT3/CHK1 ligand-1
FLT3/CHK1 ligand-1 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as PROTAC FLT3/CHK1 Degrader-1 (HY-178858) . PROTAC FLT3/CHK1 Degrader-1 is a potent FLT3/CHK1 PROTAC degrader with anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Checkpoint Kinase (Chk) ; FLT3; Ligands for Target Protein for PROTAC
Related Pathways
Cell Cycle/DNA Damage; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
N[C@H]1CC[C@@H](NC2=NC(NC3=CC=C(OCC(C)(O)C)C=C3)=NC=C2C(F)(F)F)CC1
Molecular Formula
C21H28F3N5O2
Molecular Weight
439.47
References & Citations
[1]Lian X, et al. Development of Dual FLT3 and CHK1 PROTACs for the Treatment of AML. J Med Chem. 2025 Oct 23;68 (20) :21939-21961.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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