E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO

E3 ligase Ligand 29-azacyclohexane-O-cyclohexane-CO is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC LRRK2 Degrader-3 (HY-178797) . PROTAC LRRK2 Degrader-3 is a potent LRRK2 PROTAC degrader with anti-neuroinflammatory activity[1].

Product Specifications

CAS Number

[3040075-64-4]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Neurological Disease

Smiles

O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C(N4CCC(CC4)O[C@@H]5CC[C@H](CC5)C=O)C=C3N1C

Molecular Formula

C25H32N4O5

Molecular Weight

468.55

References & Citations

[1]Renner, A. C., et al. RRK2 Degraders for Parkinson’s Disease and Inflammation: Tau and α-Synuclein Degraders for Neurodegeneration. ACS Med. Chem. Lett.