ROCK2-IN-12

ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC50 of 7.0 nM for ROCK2 over ROCK1. ROCK2-IN-12 has potent antifibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrotic progression in Bleomycin (HY-108345) -induced pulmonary fibrosis (PF) mouse models. ROCK2-IN-12 can be used for lung diseases like pulmonary fibrosis research[1].

Product Specifications

CAS Number

[3086603-12-2]

UNSPSC

12352005

Target

ROCK; STAT; TGF-beta/Smad

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Inflammation/Immunology

Smiles

FC(C=C1)=CC=C1CNCC2=NC(C3=CN=C4C=CC(NC5=CC6=C(C=C5)NN=C6)=NN43)=NO2

Molecular Formula

C23H18FN9O

Molecular Weight

455.45

References & Citations

[1]Cao Z, et al. Identification of Novel Imidazo[1,2-b]pyridazine Derivatives as Selective ROCK2 Inhibitors for the Treatment of Pulmonary Fibrosis. J Med Chem. 2025 Oct 23;68 (20) :21892-21916.