PROTAC BCL6 Degrader-2
PROTAC BCL6 Degrader-2 (Compound A19) is an orally active, selective BCL6 PROTAC degrader (DC50s: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells) . PROTAC BCL6 Degrader-2 promotes the ubiquitination and degradation of BCL6. PROTAC BCL6 Degrader-2 exhibits anticancer activity against BCL6-dependent diffuse large B-cell lymphoma (Pink: BCL6 ligand (HY-178804) ; Blue: E3 ligase ligand (HY-W087383) ; E3 ligase ligand + linker (HY-W998306) ) [1].
Product Specifications
UNSPSC
12352005
Target
BCL6; PROTACs
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer
Smiles
O=C1N(C(C2=CC(N3CCN(CC3)CC4CCN(CC4)C(C5CCN(C6=NC(NC7=CC(C=C8OCC(NC)=O)=C(C=C7)N(C)C8=O)=C(C=N6)Cl)CC5)=O)=CC=C21)=O)C9CCC(NC9=O)=O
Molecular Formula
C46H52ClN11O8
Molecular Weight
922.43
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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