PROTAC LRRK2 Degrader-3

PROTAC LRRK2 Degrader-3 is a PROTAC LRRK2 degrader with a DC50 of 0.17 nM. PROTAC LRRK2 Degrader-3 can be used for research in Parkinson’s disease and inflammation. (Pink: LRRK2 ligand: LRRK2-IN-19 (HY-177016) ; Black: Linker (HY-178830) ; Blue: E3 ligand (HY-163927) ; E3+Linker (HY-178828) ) [1].

Product Specifications

CAS Number

[3080678-98-1]

UNSPSC

12352005

Target

LRRK2; PROTACs

Related Pathways

Autophagy; PROTAC

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

CC1(CC1)OC2=CC=C3C(C(C4=NC=NC(N5CCN(C[C@H]6CC[C@H](OC7CCN(C8=CC(N(C)C(N9C%10C(NC(CC%10)=O)=O)=O)=C9C=C8)CC7)CC6)CC5)=C4)=NN3)=C2

Molecular Formula

C44H54N10O5

Molecular Weight

802.96

References & Citations

[1]Renner, A. C., et al. RRK2 Degraders for Parkinson’s Disease and Inflammation: Tau and α-Synuclein Degraders for Neurodegeneration. ACS Med. Chem. Lett.