PROTAC LRRK2 Degrader-3
PROTAC LRRK2 Degrader-3 is a PROTAC LRRK2 degrader with a DC50 of 0.17 nM. PROTAC LRRK2 Degrader-3 can be used for research in Parkinson’s disease and inflammation. (Pink: LRRK2 ligand: LRRK2-IN-19 (HY-177016) ; Black: Linker (HY-178830) ; Blue: E3 ligand (HY-163927) ; E3+Linker (HY-178828) ) [1].
Product Specifications
CAS Number
[3080678-98-1]
UNSPSC
12352005
Target
LRRK2; PROTACs
Related Pathways
Autophagy; PROTAC
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
CC1(CC1)OC2=CC=C3C(C(C4=NC=NC(N5CCN(C[C@H]6CC[C@H](OC7CCN(C8=CC(N(C)C(N9C%10C(NC(CC%10)=O)=O)=O)=C9C=C8)CC7)CC6)CC5)=C4)=NN3)=C2
Molecular Formula
C44H54N10O5
Molecular Weight
802.96
References & Citations
[1]Renner, A. C., et al. RRK2 Degraders for Parkinson’s Disease and Inflammation: Tau and α-Synuclein Degraders for Neurodegeneration. ACS Med. Chem. Lett.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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