PROTAC LRRK2 Degrader-4
PROTAC LRRK2 Degrader-4 is a PROTAC LRRK2 degrader with a DC50 of 0.79 nM. PROTAC LRRK2 Degrader-4 can be used for research in Parkinson’s disease and inflammation. (Pink: LRRK2 ligand: LRRK2-IN-19 (HY-177016) ; Black: Linker (HY-178831) ; Blue: E3 ligand (HY-179222) ; E3+Linker (HY-178832) [1].
Product Specifications
CAS Number
[2839664-99-0]
UNSPSC
12352005
Target
LRRK2; PROTACs
Related Pathways
Autophagy; PROTAC
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
CC1(CC1)OC2=CC=C3C(C(C4=NC=NC(N5CCC(CN6CCN(CC7CCN(C8=CC=C(C(N(C9C(NC(CC9)=O)=O)C%10)=O)C%10=C8OC)CC7)CC6)CC5)=C4)=NN3)=C2
Molecular Formula
C45H56N10O5
Molecular Weight
816.99
References & Citations
[1]Renner, A. C., et al. RRK2 Degraders for Parkinson’s Disease and Inflammation: Tau and α-Synuclein Degraders for Neurodegeneration. ACS Med. Chem. Lett.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-178796/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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