MrgprX2 antagonist-9
MrgprX2 antagonist-9 (compound 10) is a potent Mas-related G protein-coupled receptor X2 (MrgprX2) antagonist with an IC50 value of 0.1-100 nM. MrgprX2 antagonist-9 has the potential for the research of inflammatory[1].
Product Specifications
CAS Number
3095296-92-4
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(N1CC(C(C)(CNC2=CC(C(F)(F)F)=NC3=CC(C(F)(F)F)=NN32)C4=CC=CC=C4)C1)N
Molecular Formula
C21H20F6N6O
Molecular Weight
486.41
References & Citations
[1]Sabnis RW. Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases. ACS Med Chem Lett. 2025 Jun 2;16 (6) :980-981.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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