MrgprX2 antagonist-9

MrgprX2 antagonist-9 (compound 10) is a potent Mas-related G protein-coupled receptor X2 (MrgprX2) antagonist with an IC50 value of 0.1-100 nM. MrgprX2 antagonist-9 has the potential for the research of inflammatory[1].

Product Specifications

CAS Number

[3095296-92-4]

UNSPSC

12352005

Target

Mas-related G-protein-coupled Receptor (MRGPR)

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Smiles

O=C(N1CC(C(C)(CNC2=CC(C(F)(F)F)=NC3=CC(C(F)(F)F)=NN32)C4=CC=CC=C4)C1)N

Molecular Formula

C21H20F6N6O

Molecular Weight

486.41

References & Citations

[1]Sabnis RW. Novel Bicyclic Heterocycles as MRGPRX2 Antagonists for Treating Inflammatory Diseases. ACS Med Chem Lett. 2025 Jun 2;16 (6) :980-981.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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