MRS8454

MRS8454 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) . MRS8454 can significantly enhance the maximum effect of the standard agonist Cl-IB-MECA by approximately 286%-300%, and significantly reduce its EC50 value. MRS8454 effectively enhances the ability of A3AR agonists to inhibit the cAMP accumulation induced by Forskolin (HY-15371) . MRS8454 can be used for the development of molecular probes[1].

Product Specifications

UNSPSC

12352005

Target

Adenosine Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Smiles

CCCC(C(N1CC2=CC=CC=C2)=NC3=C1C4=CC=CC=C4N=C3NC5=CC=C(C#CCCCCCCCCCN6CCCCC6)C=C5)CCC

Molecular Formula

C46H59N5

Molecular Weight

681.99

References & Citations

[1]Kurma SH, et al. Bitopic A3 Adenosine Receptor Molecular Probes: Positive Allosteric Modulation and Noncanonical Activation. J Med Chem. 2025 Oct 9;68 (19) :20717-20740.