MRS8454
MRS8454 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR). MRS8454 can significantly enhance the maximum effect of the standard agonist Cl-IB-MECA by approximately 286%-300%, and significantly reduce its EC50 value. MRS8454 effectively enhances the ability of A3AR agonists to inhibit the cAMP accumulation induced by Forskolin. MRS8454 can be used for the development of molecular probes[1].
Product Specifications
UNSPSC
12352005
Target
Adenosine Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Smiles
CCCC(C(N1CC2=CC=CC=C2)=NC3=C1C4=CC=CC=C4N=C3NC5=CC=C(C#CCCCCCCCCCN6CCCCC6)C=C5)CCC
Molecular Formula
C46H59N5
Molecular Weight
681.99
References & Citations
[1]Kurma SH, et al. Bitopic A3 Adenosine Receptor Molecular Probes: Positive Allosteric Modulation and Noncanonical Activation. J Med Chem. 2025 Oct 9;68 (19) :20717-20740.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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