Antibacterial agent 297
Antibacterial agent 297 (Compound A40), an antibacterial agent, is a Lsrk inhibitor (IC50: 0.40 μM; KD: 3.79 μM) . Antibacterial agent 297 inhibits biofilm formation and bacterial motility and changes biofilm morphology through AI-2 QS inhibition rather than direct antibacterial effects. Antibacterial agent 297 has favorable oral PK properties[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
BrC1=CC=C(C=C1)CCC(NC2=CC3=C(N(CCCC(O)=O)C=C3)C=C2)=O
Molecular Formula
C21H21BrN2O3
Molecular Weight
429.31
References & Citations
[1]Xing C, et al. Design, Synthesis, and Biological Evaluation of Indole Derivatives Targeting LsrK as AI-2 Quorum Sensing Inhibitors. J Med Chem. 2025 Oct 23;68 (20) :21701-21724.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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