BCL6-760
BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317) ; Blue: CRBN ligand (HY-179305) ; Black: Linker) [1].
Product Specifications
CAS Number
[3084696-50-1]
UNSPSC
12352005
Target
BCL6; PROTACs
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer
Smiles
CN(C1=NC(NC2=CC=C3N(C(N(C3=C2)CCC(C)(O)C)=O)C)=C(C=N1)Cl)C4CCN(C5=CC6=C(C(C7CCC(NC7=O)=O)=NN6C)C=C5)CC4
Molecular Formula
C36H43ClN10O4
Molecular Weight
715.24
References & Citations
[1]Shunatona HP, et al. Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760. J Med Chem. 2025 Oct 23;68 (20) :21502-21519.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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