DCLK1-IN-6
DCLK1-IN-6 (Compound 12n) is a Doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 58 nM. DCLK1-IN-6 significantly inhibits DCLK1 enzyme activity and its mediated inflammatory pathway. DCLK1-IN-6 has remarkable anti-inflammatory activity and significantly alleviates symptoms in acute lung injury (ALI) and sepsis mouse models. DCLK1-IN-6 can be used for acute inflammation diseases research[1].
Product Specifications
UNSPSC
12352005
Target
IKK; Interleukin Related; NF-κB; Ser/Thr Protease; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
CN(C1=NC(NC2=C(C=C(C=C2)C(N3CCC4(CC3)CCNCC4)=O)OC)=NC=C1N(C5=O)C)C6=C5C=CC=C6
Molecular Formula
C30H35N7O3
Molecular Weight
541.64
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β; IL-6
Frequently Asked Questions
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