DCLK1-IN-6

DCLK1-IN-6 (Compound 12n) is a Doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 58 nM. DCLK1-IN-6 significantly inhibits DCLK1 enzyme activity and its mediated inflammatory pathway. DCLK1-IN-6 has remarkable anti-inflammatory activity and significantly alleviates symptoms in acute lung injury (ALI) and sepsis mouse models. DCLK1-IN-6 can be used for acute inflammation diseases research[1].

Product Specifications

UNSPSC

12352005

Target

IKK; Interleukin Related; NF-κB; Ser/Thr Protease; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology

Smiles

CN(C1=NC(NC2=C(C=C(C=C2)C(N3CCC4(CC3)CCNCC4)=O)OC)=NC=C1N(C5=O)C)C6=C5C=CC=C6

Molecular Formula

C30H35N7O3

Molecular Weight

541.64

References & Citations

[1]Wu S, et al. Discovery of Benzodiazepinepyrimidine Scaffold Derivatives as Potent Doublecortin-Like Kinase 1 (DCLK1) Inhibitors for the Treatment of Acute Inflammatory Diseases. J Med Chem. 2025 Oct 23;68 (20) :21560-21576.