PI4K-IN-3

PI4K-IN-3 (Compound 27) is an orally active PI4K inhibitor with an IC50 of 1.9 nM for Plasmodium vivax PI4K. PI4K-IN-3 has no hERG channel inhibition and mammalian cytotoxicity. PI4K-IN-3 has significant selectivity against the human MINK1 and MAP4K4 kinases but with low selectivity against human PI3Kα and PI4Kβ. PI4K-IN-3 has potent antimalarial activity and significantly reduces parasitaemia in NSG mice mouse models of Plasmodium falciparum malaria[1].

Product Specifications

UNSPSC

12352005

Target

MAP4K; Parasite; PI3K; PI4K

Related Pathways

Anti-infection; MAPK/ERK Pathway; PI3K/Akt/mTOR

Field of Research

Infection

Smiles

OC(C)(C1=CC=C(C2=C3C(C=CC(C4=CC(CC(NC)=O)=CC=C4)=N3)=NC=C2)C=N1)C

Molecular Formula

C25H24N4O2

Molecular Weight

412.48

References & Citations

[1]Dziwornu GA, et al. Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy. J Med Chem. 2025 Oct 23;68 (20) :21878-21891.