SIRT2-IN-18
SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3 and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis[1].
Product Specifications
CAS Number
858032-59-4
UNSPSC
12352005
Target
Apoptosis; Sirtuin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Infection
Smiles
O=C(C1=CC2=C(OC1=NC3=O)C=CC4=C2C=CC=C4)N3C5=CC=CC=C5
Molecular Formula
C21H12N2O3
Molecular Weight
340.33
References & Citations
[1]Gimmelli R, et al. Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit Schistosoma mansoni Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages. ACS Infect Dis. 2025 Oct 7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT2
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