SIRT2-IN-18

SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3 and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis[1].

Product Specifications

CAS Number

[858032-59-4]

UNSPSC

12352005

Target

Apoptosis; Sirtuin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Infection

Smiles

O=C(C1=CC2=C(OC1=NC3=O)C=CC4=C2C=CC=C4)N3C5=CC=CC=C5

Molecular Formula

C21H12N2O3

Molecular Weight

340.33

References & Citations

[1]Gimmelli R, et al. Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit Schistosoma mansoni Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages. ACS Infect Dis. 2025 Oct 7.